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Author Koizumi, Yukio ♦ Arai, Masayoshi ♦ Tomoda, Hiroshi ♦ Omura, Satoshi
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract A fungal alkaloid fungerin was found to arrest the cell cycle of Jurkat cells at the $G_{2}/M$ phase, then to induce apoptosis. Immunoblotting showed that fungerin led to hyperphosphorylation for Cdc25C and dephosphorylation of Cdc2, indicating that the compound arrests the cell cycle at the M phase. Moreover, fungerin inhibited the polymerization of microtubule proteins in vitro. It was concluded that fungerin arrests the cell cycle at the M phase through inhibition of microtubule polymerization.
ISSN 00218820
Learning Resource Type Article
Publisher Date 2004-07-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 57
Issue Number 7
Page Count 6
Starting Page 415
Ending Page 420


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