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Author Yamasaki, Kazuo ♦ Kaneda, Miyuki ♦ Watanabe, Koji ♦ Ueki, Yuko ♦ Ishimaru, Kurumi ♦ Nakamura, Shoshiro ♦ Nomi, Ryosaku ♦ Yoshida, Naoko ♦ Nakajima, Terumi
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract The carbazomycin-producing microorganism, strain H 1051-MY 10, was determined to a strain of Streptoverticillium ehimense. Biosynthesis of carbazomycin B was studied using $^{14}C-labeled$ and $^{13}C-enriched$ precursors in combination with $^{13}C$ NMR spectroscopy. The C-2 carbon of $[2-^{13}C]tryptophan$ was shown to be involved at the C-3 carbon in carbazomycin B and both carbons of [1, $2-^{13}C]$ acetate at the C-1 and C-10 moiety of the antibiotic. $[CH_{3}-^{13}C]Methionine$ was involved at the methoxyl group but not at the methyl group on the C-2 carbon of the antibiotic. Neither of the labeled carbons, $[1-^{14}C]tryptophan$ nor [2, $3-^{13}C]propionic$ acid, was detected in the antibiotic, and a progenitor of the C-2 and C-11 moiety of the antibiotic has not been determined.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1983-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 36
Issue Number 5
Page Count 7
Starting Page 552
Ending Page 558


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