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Author Ogawa, Tatsuhiro ♦ Ando, Katsuhiko ♦ Aotani, Yumiko ♦ Shinoda, Katsumi ♦ Tanaka, Takeo ♦ Tsukuda, Em ♦ Yoshida, Mayumi ♦ Matsuda, Yuzuru
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract RES-1214-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the culture broth of a fungus, Pestalotiopsis sp. RE-1214. RES-1214-1 and -2 selectively inhibited the ET-1 binding to endothelin type A receptor $(ET_{A}$ receptor) with $IC_{50}$ values of 1.5μM and 20μM, respectively. RES-1214-1 and -2 inhibited the increase in intracellular $Ca^{2+}$ concentration elicited by 1 nM ET-1 in A10 cells. Taxonomy of producing strains, fermentation, isolation, structural determination, and biochemical properties of RES-1214-1 and -2 are described.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1995-12-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 48
Issue Number 12
Page Count 6
Starting Page 1401
Ending Page 1406


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