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Author Prudhomme, M. ♦ Dauphin, G. ♦ Ieminet, G.
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Ten semi-synthetic analogs of A23187 (calcimycin), with only the benzoxazole ring substituents modified together with the ionophore X14885A were studied with regard to their calcium and magnesium carrier properties through an organic phase (toluene-butanol, 70:30). The results indicate that the carboxylic group and the oxazolic nitrogen, maintained in the ortho position are essential for the ionophorous properties. Further, the introduction of a substituent in place of the $NHCH_{3}$ group, producing steric hindrance of the carboxylic group leads to a destabilization of the 2:1 associations with cations.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1986-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 39
Issue Number 7
Page Count 12
Starting Page 922
Ending Page 933


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