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Author Vanittanakom, Nongnuch ♦ Loeffler, Wolfgang ♦ Koch, Ulrike ♦ Jung, Günther
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase the antifungal effect. Fengycin consists of two main components differing by one amino acid exchange. Fengycin A is composed of 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-Glx, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas in fengycin B the D-Ala is replaced by D-Val. The lipid moiety of both analogs is more variable, as fatty acids have been identified as anteiso-pentadecanoic acid $(ai-C_{15}),$ iso-hexadecanoic acid $(i-C_{16}$ ), n-hexadecanoic acid $(n-C_{16}),$ and there is evidence for further saturated and unsaturated residues up to $C_{18}.$
ISSN 00218820
Learning Resource Type Article
Publisher Date 1986-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 39
Issue Number 7
Page Count 14
Starting Page 888
Ending Page 901


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