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Author Kaneko, Isao ♦ Kamoshida, Katuo ♦ Takahashi, Shuji
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract A new potent inhibitor of complement system, named complestatin, was isolated from the mycelium of Streptomyces lavendulae SANK 60477. Complestatin $(C_{61}H_{45}N_{7}O_{15}Cl_{6},$ MW 1, 325) was a peptide compound having two unusual amino acids, D-(-)-4-hydroxyphenylglycine and D-(-)-3, 5-dichloro-4-hydroxyphenylglycine. This compound inhibited the hemolysis of sensitized sheep erythrocytes (EA) mediated by guinea pig and human complement 50% at concentrations of 0.4 and 0.7 μg/ml, respectively, but did not trypsin and α-chymotrypsin activities at 200 μg/ml. When complestatin was administered intravenously to the sensitized guinea pigs, it strongly inhibited the systemic anaphylactic shock elicited by the antigen probably by blocking generation of anaphylatoxins (C3a and C5a).
ISSN 00218820
Learning Resource Type Article
Publisher Date 1989-02-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 42
Issue Number 2
Page Count 6
Starting Page 236
Ending Page 241


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