Thumbnail
Access Restriction
Open

Author Burton, George ♦ Basker, Michael J. ♦ Bentley, Peter H. ♦ Best, Desmond J. ♦ Dixon, Ronald A. ♦ Harrington, Frank P. ♦ Kenyon, Robert F. ♦ Lashford, Andrew G. ♦ Taylor, Andrew W.
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract The influence on the antibacterial activity of introducing a 6α-methoxy group into carbenicillin, and various 6α-substituents into sulbenicillin and piperacillin was examined. Further variations of the side chain aryl group were examined in the 6α-methoxy substituted series. This led to the identification of disodium 6β-(D, L-2-carboxy-2-thien-3-ylacetamido)-6α-methoxypenicillanate (5b) as a β-lactamase stable derivative with useful activity against Enterobacteriaceae, and disodium 6β-[D-2-(4-aminophenyl)-2-sulfoacetamido]-6α-methoxypenicillanate (6e) with slightly lower activity against the Enterobacteriaceae but more active against Pseudontonas aeruginosa.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1985-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 38
Issue Number 6
Page Count 19
Starting Page 721
Ending Page 739


Open content in new tab

   Open content in new tab