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Author Malabarba, Adriano ♦ Spreafico, Franca ♦ Ferrari, Pietro ♦ Kettenring, Jürgen ♦ Strazzolini, Paolo ♦ Tarzia, Giorgio ♦ Pallanza, Rosa ♦ Berti, Marisa ♦ Cavalleri, Bruno
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Mono- and didechlorinated derivatives of the antibiotic teicoplanin, its pseudoaglycones and aglycone, and of one amide and ester of deglucoteicoplanin were prepared under selective reductive conditions. The selectivity and rate of dehalogenation were studied and compared to those of vancomycin and deglucovancomycin. The influence of the chlorine substituents on the mechanism of action and antibacterial activity of teicoplanin antibiotics was also investigated.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1989-11-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 42
Issue Number 11
Page Count 14
Starting Page 1684
Ending Page 1697


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