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Author Kurihara, KEN-ICHI ♦ Ajito, Keiichi ♦ Shibahara, Seiji ♦ Hara, Osamu ♦ Araake, Minako ♦ Omoto, Shoji ♦ Inouye, Shigeharu
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Five novel 3-hydroxyl derivatives of sixteen-membered macrolide possessing 4-O-acyl-α-L-cladinose as a neutral sugar moiety were synthesized by using a combination of structurally stable silyl acetal protection and selective hydrogenolysis of a 3″-methylthiomethyl ether to a 3″-OMe group. Several derivatives having n-butyryl, i-butyryl and n-valeryl substituent at the 4″-OH group exhibited significant antibacterial activity in vitro. One of them, 4″-O-n-butyryl-3″-O-methylleucomycin V, showed improved therapeutic effect in mice.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1998-08-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 51
Issue Number 8
Page Count 15
Starting Page 771
Ending Page 785


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