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Author Fuchs, P. C. ♦ Thornsberry, C. ♦ Barry, A. L. ♦ Jones, R. N. ♦ Gavan, T. L. ♦ Gerlach, E. H. ♦ Sommers, H. M.
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Rosamicin in vitro activity was compared with that of erythromycin and other antimicrobics against clinical urinary tract isolates, genital pathogens and Neisseria meningitidis. Although the susceptibility or resistance to the two macrolides almost perfectly paralleled each other, the activity of rosamicin was greater than that of erythromycin against most species tested, including the Enterobacteriaceae, non-fermentative Gram-negative bacilli, N. gonorrhoeae, N. meningitidis and Haemophilus vaginalis. No differences were seen between the two against Staphylococcus aureus, and erythromycin was superior against Streptococcus pyogenes. Significant increased activity of both drugs was observed against Gram-negative bacilli upon alkalinization of the media. The differences between bacteriostatic and bactericidal levels of rosamicin were greater against Gram-negative bacilli than Gram-positive cocci. The effect of inoculum size on increasing the minimal inhibitory concentrations (MIC) of rosamicin was significant above inocula of $10^{5}$ bacteria/ml, but not below this level. Dilution-zone size regression analyses showed good correlation with rosamicin, yielding suggested susceptibility breakpoints of 1μg/ml and 24mm zone of inhibition with 15-μg discs. The erythromycin regression analysis data in this study suggest that the NCCLS zone size criteria may be too low. The exquisite susceptibility of genital pathogens to rosamicin plus the pharmacologic concentration of rosamicin in prostate, urethra and vaginal secretions renders this drug worthy of further investigation for possible use in genital tract infections.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1979-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 32
Issue Number 9
Page Count 8
Starting Page 920
Ending Page 927


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