Thumbnail
Access Restriction
Open

Author Nishizawa, Rinzo ♦ Takei, Yukio ♦ Yoshida, Masao ♦ Tomiyoshi, Tsugio ♦ Saino, Tetsushi ♦ Nishikawa, Kiyohiro ♦ Nemoto, Kyuichi ♦ Takahashi, Katsutoshi ♦ Fujii, Akio ♦ Nakamura, Teruya ♦ Takita, Tomohisa ♦ Takeuchi, Tomio
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Stable spergualin analogues were synthesized by substitutions of the α-hydroxyglycine residue of spergualin with various α- or ω-amino acids. The antitumor activity of these analogues against L1210 and their immunosuppressive effects on delayed-type hypersensitivity and antibody formation was then examined. Analogues substituted with glycine and L-serine showed significant biological activity but were less potent than 15-deoxyspergualin. Among the analogues synthesized so far, 10-[N-4-(4-guanidinophenyl)butyryl-L-seryl]-1, 5, 10-triazadecane has possessed the strongest antitumor and immunosuppressive activities.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1988-11-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 41
Issue Number 11
Page Count 15
Starting Page 1629
Ending Page 1643


Open content in new tab

   Open content in new tab