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Author Zocher, Rainer ♦ Keller, Ullrich ♦ Lee, Chan ♦ Hoffmann, Kai
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract A peptidyl-prolyl cis-trans isomerase (PPIase) was purified to homogeneity about 24-fold from the cyclosporin-producing fungus Tolypocladium inflatum. The molecular mass of the enzyme was in the range of 17 kdaltons. Remarkably, the enzyme could be inhibited by cyclosporin A in the nanomolar range as has been shown for numerous other cyclophilins from eukaryotic organisms. This indicates, that Tolypocladium inflatum must possess a self protection system in order to survive in the presence of cyclosporin.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1992-02-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 45
Issue Number 2
Page Count 4
Starting Page 265
Ending Page 268


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