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Author Imoto, Masaya ♦ Kakeya, Hideaki ♦ Sawa, Tsutomu ♦ Hayashi, Chigusa ♦ Hamada, Masa ♦ Takeuchi, Tomio ♦ Umezawa, Kazuo
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract A novel inhibitor of protein tyrosine phosphatase, dephostatin, was isolated from the culture broth of a strain of Streptomyces. The active principle was extracted from the broth filtrate with ethyl acetate and purified by silica gel chromatography and by HPLC. Dephostatin inhibited protein tyrosine phosphatase prepared from a human neoplastic T-cell line with an $IC_{50}$ at 7.7 μM. The inhibitory pattern of dephostatin was competitive against the substrate. Dephostatin inhibited the growth of Jurkat cells.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1993-09-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 46
Issue Number 9
Page Count 5
Starting Page 1342
Ending Page 1346


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