Thumbnail
Access Restriction
Open

Author Sztaricskai, Ferenc ♦ Dinya, Zoltán ♦ Batta, Gyula ♦ Mocsári, Anikó ♦ Hollósi, Miklós ♦ Majer, Zsuzsa ♦ Masuma, Rokuro ♦ Omura, Satoshi
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Oxidation of lincomycin with dimethyldioxirane resulted in the sulfoxide-glycosides 3a and 3b, whose treatment with osmium tetraoxide and N-methylmorpholine-N-oxide afforded the same sulfone; 4. According to FAB-MS and CD investigations, the absolute configuration of the sulfur atom in 3a and 3b is R and S, respectively. The new, unsaturated antibiotic analog (6) derived from clindamycin exists in the $^{4}C_{1}$ conformation. The antibiotic activities of the synthesized compounds were also studied.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1997-10-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 50
Issue Number 10
Page Count 8
Starting Page 866
Ending Page 873


Open content in new tab

   Open content in new tab