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Author Uyeda, Masaru ♦ Kubota, Kunihiko ♦ Miyamura, Shigeyuki ♦ Shibata, Motoo
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Two transformation products of maridomycin (MDM) III, $MDM-S_{1}$ and $MDM-S_{2}$ named after Serratia marcescens, were isolated by silica gel chromatography. NMR and IR analysis revealed that $MDM-S_{1}$ and $-S_{2}$ had no aldehyde group at C-18 on the macrolactone ring, and that the hydroxyl group at C-9 seemed to disappear. Although $MDM-S_{1}$ and $-S_{2}$ are less active against Gram-positive bacteria than starting MDM III. they are interesting materials in view of the introduction of nitrogen into each molecule, and that the transformation products are produced by Gram-negative bacteria which are thought to be insensitive to macrolide antibiotics.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1983-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 36
Issue Number 12
Page Count 7
Starting Page 1722
Ending Page 1728


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