Thumbnail
Access Restriction
Open

Author Hakoda, Seiji ♦ Tsubotani, Shigetoshi ♦ Iwasa, Takashi ♦ Suzuki, Masaru ♦ Kondo, Masahiro ♦ Harada, Setsuo
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract A novel antifungal antibiotic, TAN-950 complex, was isolated from the culture filtrate of Streptomyces platensis A-136 (IFO 14603, PERM BP-1786). The water-soluble amphoteric substances in this complex were purified by chromatography using ion-exchange resins, QAE-Sephadex and adsorptive resins and were designated TAN-950 A and TAN-950 A-E mixture. The molecular formula of TAN-950 A was determined to be $C_{6}H_{7}N_{2}O_{4}Na$ for the sodium salt. This new amino acid antibiotic showed antifungal activity against Candida albicans in vitro and in vivo, and had low toxicity in mice.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1992-06-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 45
Issue Number 6
Page Count 7
Starting Page 854
Ending Page 860


Open content in new tab

   Open content in new tab