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Author Hino, Motohiro ♦ Nakayama, Osamu ♦ Tsurumi, Yasuhisa ♦ Adachi, Kimiko ♦ Shibata, Toshihiro ♦ Terano, Hiroshi ♦ Kohsaka, Masanobu ♦ Aoki, Hatsuo ♦ Imanaka, Hiroshi
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Swainsonine isolated from Metarhizium sp., was found to enhance the activities of the mouse immune system in vitro. Concanavalin A stimulated lymphocyte proliferation and proliferative response in mixed lymphocytes culture, which were suppressed by immunosuppressive factor obtained from serum of sarcoma 180 tumor bearing mouse, were restored to normal levels by the addition of swainsonine. Furthermore, the concanavalin A induced incorporation of $[^{3}H]$ thymidine into mouse spleen cells was remarkably increased by treatment with swainsonine over a wide dose range. From studies using fluorescence activated cell sorting, swainsonine was shown to enhance the expression of concanavalin A receptors of spleen cells.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1985-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 38
Issue Number 7
Page Count 10
Starting Page 926
Ending Page 935


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