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Author Bian, Shi Zhu ♦ Jin, Jun ♦ Li, Qian Ning ♦ Qin, Jun ♦ Zhang, Ji Hang ♦ Yu, Shi Yong ♦ Chen, Jian Fei ♦ Tang, Cai Fa ♦ Huang, Lan
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Cerebral hemodynamic characteristics ♦ Acute mountain sickness ♦ High altitude ♦ Human Physiology ♦ Occupational Medicine/Industrial Medicine ♦ Sports Medicine
Abstract We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS).Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m (n = 454). A subgroup of 151 subjects received TCD examinations at both altitudes.The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS−) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [V d_VA (26 ± 4 vs. 25 ± 4, p = 0.013)] with lower PI and RI (both p = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [−5.7 % (21.0 %) vs. −2.5 % (17.8 %), p = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA, PI, RI and AI of VA.AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.
ISSN 14396319
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-07-05
Publisher Place Berlin/Heidelberg
e-ISSN 14396327
Journal European Journal of Applied Physiology
Volume Number 114
Issue Number 10
Page Count 8
Starting Page 2193
Ending Page 2200


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Source: SpringerLink