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Author Taffetani, Matteo ♦ Falco, Carlo ♦ Penta, Raimondo ♦ Ambrosi, Davide ♦ Ciarletta, Pasquale
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Engineering & allied operations
Subject Keyword Multiscale modelling ♦ Biological systems ♦ Transport ♦ Nanoparticles ♦ Nanomedicine ♦ Theoretical and Applied Mechanics ♦ Mechanics
Abstract Nanomedicine is the branch of nanotechnology devoted to the miniaturization of devices and to the functionalization of processes for the diagnosis and the design of tools of clinical use. In the perspective to develop patient-specific treatments and effective therapies against currently incurable diseases, biomechanical modelling plays a key role in enabling their translation to clinical practice. Establishing a dynamic interaction with experiments, a modelling approach is expected to allow investigating problems with lower economic burden, evaluating a larger range of conditions. Since biological systems have a wide range of typical characteristic length and timescales, a multiscale modelling approach is necessary both for providing a proper description of the biological complexity at the single scales and for keeping the largest amount of functional interdependence among them. This work starts with a survey both of the common frameworks for modelling a biological system, at scales from atoms to a continuous distribution of matter, and of the available multiscale methods that link the different levels of investigation. In the following, we define an original approach for dealing with the specific case of transport and diffusion of nanoparticles and/or drug-delivery carriers from the systemic circulation to a target tissue microstructure. Using a macro–micro viewpoint, we discuss the existing multiscale approaches and we propose few original strategies for overcoming their limitations in bridging scales. In conclusion, we highlight and critically discuss the future challenges of multiscale modelling for achieving the long-term objective to assist the nanomedical research in proposing more accurate clinical approaches for improved medical benefit.
ISSN 09391533
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-07-01
Publisher Place Berlin/Heidelberg
e-ISSN 14320681
Journal Archive of Applied Mechanics
Volume Number 84
Issue Number 9
Page Count 19
Starting Page 1627
Ending Page 1645

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Source: SpringerLink