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Author Formichini, E. ♦ Bongenhielm, U. ♦ Risling, M. ♦ Fried, K.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©1998
Language English
Subject Domain (in DDC) Social sciences ♦ Sociology & anthropology
Abstract  The purpose of this study was to map the distribution of α-subunits of G-proteins – Gαolf s, Gαolf, Gαs, Gαi, Gαo, Gαz and Gαq11– in developing, denervated or injured rat molar teeth, using fluorescence microscopic immunohistochemistry coupled with immunogold electron microscopic immunocytochemistry. In rat fetuses (E17–E21), a widespread expression of Gαq11 was seen in maxillary/mandibular mesenchyme as well as in developing teeth. In addition, intensely Gαo-positive nerve fibers were associated with the dental epithelium and the dental papilla of developing teeth. Other G proteins were absent or sparsely distributed during early tooth development. In the adult tooth pulp, odontoblasts appeared to express mainly Gαolf s, Gαo, and Gαq11. Nerve fibers were immunoreactive to Gαi, Gαo and Gαz. In addition, pulpal blood vessels expressed varying levels of Gαolf s Gαz and Gαq11 while Gαolf s, Gαolf, Gαo and Gαq11 were found in various pulpal mesenchymal cells. After adult denervation, nerve fiber-related G-protein immunoreactivity disappeared, but no other changes in pulpal G-protein immunoreactivity were noted. Odontoblasts and mesenchyme cells were intensely Gαi-positive underneath a pulpal traumatic exposure, indicating an injury-induced pulpal upregulation of Gαi. The findings that Gαi, Gαo and Gαz are expressed in pulpal sensory nerve fibers suggest that these G proteins participate in signal conveyance from the target to the trigeminal nerve cell body.
ISSN 03402061
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 1998-11-02
Publisher Place Berlin/Heidelberg
e-ISSN 14320568
Journal Anatomy and Embryology
Volume Number 198
Issue Number 6
Page Count 8
Starting Page 515
Ending Page 522


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Source: SpringerLink