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Author Geerts, Cornelia J. ♦ Plomp, Jaap J. ♦ Koopmans, Bastijn ♦ Loos, Maarten ♦ Pijl, Elizabeth M. ♦ Valk, Martin A. ♦ Verhage, Matthijs ♦ Groffen, Alexander J. A.
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Neuromuscular junction ♦ Release willingness ♦ Short-term plasticity ♦ STXBP5L ♦ Synaptic transmission ♦ Tomosyn-2 ♦ Neurosciences ♦ Cell Biology ♦ Neurology
Abstract Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2KO/KO) mice, which showed impaired motor performance. This was accompanied by synaptic changes at the neuromuscular junction, including enhanced spontaneous acetylcholine release frequency and faster depression of muscle motor endplate potentials during repetitive stimulation. The postsynaptic geometric arrangement and function of acetylcholine receptors were normal. We conclude that tomosyn-2 supports motor performance by regulation of transmitter release willingness to sustain synaptic strength during high-frequency transmission, which makes this gene a candidate for involvement in neuromuscular disorders.
ISSN 18632653
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-04-18
Publisher Place Berlin/Heidelberg
e-ISSN 18632661
Journal Anatomy and Embryology
Volume Number 220
Issue Number 4
Page Count 12
Starting Page 1971
Ending Page 1982


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Source: SpringerLink