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Author Baume, rbert ♦ Steel, Graeme ♦ Edwards, Tony ♦ Thorstensen, Eric ♦ Miller, Benjamin F.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2008
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword ACTH ♦ Cortisol ♦ Androgens ♦ Doping ♦ Cycling ♦ Sports Medicine ♦ Occupational Medicine/Industrial Medicine ♦ Human Physiology
Abstract There is anecdotal evidence that athletes use the banned substance Synacthen® because of its perceived benefit with its associated rise in cortisol. To test the performance-enhancing effects of Synacthen®, eight trained cyclists completed two, 2-day exercise sessions separated by 7–10 days. On the first day of each 2-day exercise session, subjects received either Synacthen® (0.25 mg, TX) or placebo (PLA) injection. Performance was assessed by a 20-km time trial (TT) after a 90-min fatigue period on day 1 and without the fatiguing protocol on day 2. Plasma androgens and ACTH concentrations were measured during the exercise bouts as well as the rate of perceived exertion (RPE). Spot urines were analyzed for androgens and glucocorticoids quantification. Basal plasma hormones did not differ significantly between PLA and TX groups before and 24 h after the IM injection (P > 0.05). After TX injection, ACTH peaked at 30 min and hormone profiles were significantly different compared to the PLA trial (P < 0.001). RPE increased significantly in both groups as the exercise sessions progressed (P < 0.001) but was not influenced by treatment. The time to completion of the TT was not affected on both days by Synacthen® treatment. In the present study, a single IM injection of synthetic ACTH did not improve either acute or subsequent cycling performance and did not influence perceived exertion. The investigated urinary hormones did not vary after treatment, reinforcing the difficulty for ACTH abuse detection.
ISSN 14396319
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-06-27
Publisher Place Berlin/Heidelberg
e-ISSN 14396327
Journal European Journal of Applied Physiology
Volume Number 104
Issue Number 4
Page Count 12
Starting Page 589
Ending Page 600

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Source: SpringerLink