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Author Meyer, Bernhard M. ♦ Huemer, Julia ♦ Rabl, Ulrich ♦ Boubela, Roland N. ♦ Kalcher, Klaudius ♦ Berger, Andreas ♦ Banaschewski, Tobias ♦ Barker, Gareth ♦ Bokde, Arun ♦ Büchel, Christian ♦ Conrod, Patricia ♦ Desrivières, Sylvane ♦ Flor, Herta ♦ Frouin, Vincent ♦ Gallinat, Jurgen ♦ Garavan, Hugh ♦ Heinz, Andreas ♦ Ittermann, Bernd ♦ Jia, Tianye ♦ Lathrop, Mark ♦ Martit, Jean Luc ♦ Nees, Frauke ♦ Rietschel, Marcella ♦ Smolka, Michael N. ♦ Bartova, Lucie ♦ Popovic, Ana ♦ Scharinger, Christian ♦ Sitte, Harald H. ♦ Steiner, Hans ♦ Friedrich, Max H. ♦ Kasper, Siegfried ♦ Perkmann, Thomas ♦ Praschak Rieder, Nicole ♦ Haslacher, Helmuth ♦ Esterbauer, Harald ♦ Moser, Ewald ♦ Schumann, Gunter ♦ Pezawas, Lukas
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Catechol-O-methyltransferase ♦ Dopamine ♦ Adolescents ♦ Cognition ♦ Functional neuroimaging ♦ Magnetic resonance imaging ♦ Neurosciences ♦ Cell Biology ♦ Neurology
Abstract Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers. Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults. The present study aims to identify such oppositional COMT Val158Met effects in adolescents and adults in prefrontal brain networks at rest. Resting state functional connectivity data were collected from cross-sectional and multicenter study sites involving 106 healthy young adults (mean age 24 ± 2.6 years), gender matched to 106 randomly chosen 14-year-olds. We selected the anterior medial prefrontal cortex (amPFC) as seed due to its important role as nexus of the executive control and default mode network. We observed a significant age-dependent reversal of COMT Val158Met effects on resting state functional connectivity between amPFC and ventrolateral as well as dorsolateral prefrontal cortex, and parahippocampal gyrus. Val homozygous adults exhibited increased and adolescents decreased connectivity compared to Met homozygotes for all reported regions. Network analyses underscored the importance of the parahippocampal gyrus as mediator of observed effects. Results of this study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by COMT genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve. This study might provide cues for the understanding of disease onset or dopaminergic treatment mechanisms in major neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder.
ISSN 18632653
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-10-16
Publisher Place Berlin/Heidelberg
e-ISSN 18632661
Journal Anatomy and Embryology
Volume Number 221
Issue Number 1
Page Count 12
Starting Page 103
Ending Page 114


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Source: SpringerLink