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Author Kwon, Obin ♦ Kim, Ki Woo ♦ Kim, Min Seon
Source SpringerLink
Content type Text
Publisher Springer International Publishing
File Format PDF
Copyright Year ©2016
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology
Subject Keyword Leptin ♦ Signaling ♦ Hypothalamus ♦ Neurons ♦ Obesity ♦ Cilia ♦ Cell Biology ♦ Biomedicine general ♦ Life Sciences ♦ Biochemistry
Abstract Leptin is the most critical hormone in the homeostatic regulation of energy balance among those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of hypothalamus to regulate food intake, thermogenesis, and the blood glucose level. In the hypothalamic neurons, leptin binding to the long form leptin receptors on the plasma membrane initiates multiple signaling cascades. The signaling pathways known to mediate the actions of leptin include JAK–STAT signaling, PI3K–Akt–FoxO1 signaling, SHP2–ERK signaling, AMPK signaling, and mTOR–S6K signaling. Recent evidence suggests that leptin signaling in hypothalamic neurons is also linked to primary cilia function. On the other hand, signaling molecules/pathways mitigating leptin actions in hypothalamic neurons have been extensively investigated in an effort to treat leptin resistance observed in obesity. These include SOCS3, tyrosine phosphatase PTP1B, and inflammatory signaling pathways such as IKK-NFκB and JNK signaling, and ER stress–mitochondrial signaling. In this review, we discuss leptin signaling pathways in the hypothalamus, with a particular focus on the most recently discovered pathways.
ISSN 1420682X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-01-19
Publisher Place Cham
e-ISSN 14209071
Journal Cellular and Molecular Life Sciences
Volume Number 73
Issue Number 7
Page Count 21
Starting Page 1457
Ending Page 1477

Source: SpringerLink