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Author Ohtsuka, Hokuto ♦ Ishida, Maiko ♦ Naito, Chikako ♦ Murakami, Hiroshi ♦ Aiba, Hirofumi
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology
Subject Keyword Schizosaccharomyces pombe ♦ Sexual development ♦ Metals ♦ Stationary phase ♦ Ecl1 family ♦ Cell Biology ♦ Biochemistry ♦ Microbial Genetics and Genomics ♦ Plant Genetics & Genomics ♦ Animal Genetics and Genomics
Abstract Ecl1 family genes (ecl1 +, ecl2 +, and ecl3 +) have been identified as extenders of the chronological lifespan in Schizosaccharomyces pombe. Here, we found that the triple-deletion mutant (∆ecl1/2/3) had a defect in sexual development after entry into the stationary phase, although the mutant essentially showed normal mating and sporulation under nitrogen starvation or carbon limitation. In this study, we showed that limitation of zinc or iron can be a signal for sexual development of S. pombe cells grown in Edinburgh minimal medium until the stationary phase and that Ecl1 family genes are important for this process. Because the ∆ecl1/2/3 mutant diminishes the zinc depletion-dependent gene expression, Ecl1 family proteins may function as zinc sensors in the process of sexual development.
ISSN 16174615
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-09-10
Publisher Place Berlin/Heidelberg
e-ISSN 16174623
Journal Molecular and General Genetics MGG
Volume Number 290
Issue Number 1
Page Count 13
Starting Page 173
Ending Page 185


Source: SpringerLink