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Author Virdi, Vikram ♦ Juarez, Paloma ♦ Boudolf, Veronique ♦ Depicker, Ann
Source SpringerLink
Content type Text
Publisher Springer International Publishing
File Format PDF
Copyright Year ©2015
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Life sciences; biology
Subject Keyword Mucosal infections ♦ Plant-based production ♦ IgA purification ♦ Topical application ♦ Immune prophylaxis ♦ Molecular farming ♦ Cell Biology ♦ Biomedicine general ♦ Life Sciences ♦ Biochemistry
Abstract Vaccination is a successful strategy to proactively develop immunity to a certain pathogen, but most vaccines fail to trigger a specific immune response at the mucosal surfaces, which are the first port of entry for infectious agents. At the mucosal surfaces, the predominant immunoglobulin is secretory IgA (SIgA) that specifically neutralizes viruses and prevents bacterial colonization. Mucosal passive immunization, i.e. the application of pathogen-specific SIgAs at the mucosae, can be an effective alternative to achieve mucosal protection. However, this approach is not straightforward, mainly because SIgAs are difficult to obtain from convalescent sources, while recombinant SIgA production is challenging due to its complex structure. This review provides an overview of manufacturing difficulties presented by the unique structural diversity of SIgAs, and the innovative solutions being explored for SIgA production in mammalian and plant expression systems.
ISSN 1420682X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-10-28
Publisher Place Cham
e-ISSN 14209071
Journal Cellular and Molecular Life Sciences
Volume Number 73
Issue Number 3
Page Count 11
Starting Page 535
Ending Page 545


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Source: SpringerLink