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Author Xue, Jian ♦ Utzinger, Jürg ♦ Zhang, Yong Nian ♦ Tanner, Marcel ♦ Keiser, Jennifer ♦ Xiao, Shu Hua
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2007
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Artemether ♦ Tribendimidine ♦ Food-borne trematodiasis ♦ Paragonimus westermani ♦ In vivo study ♦ Dog ♦ Immunology ♦ Microbiology ♦ Medical Microbiology
Abstract Artemether and tribendimidine are active against several trematode species, but no data are available regarding the lung fluke Paragonimus westermani. We infected six dogs with 100 P. westermani metacercariae each. At day 103 post-infection, four dogs were treated orally for 3 days with either artemether (total dose, 66.7 and 75 mg/kg) or tribendimidine (total dose, 100 mg/kg). The remaining dogs were left untreated and served as control. Sixteen days after the final dosing, dogs were killed, and P. westermani flukes were recovered from the lungs and counted. Neither artemether nor tribendimidine showed activity against P. westermani at this dose regimen in dogs.
ISSN 09320113
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2007-12-08
Publisher Place Berlin/Heidelberg
e-ISSN 14321955
Journal Parasitology Research
Volume Number 102
Issue Number 3
Page Count 4
Starting Page 537
Ending Page 540


Source: SpringerLink