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Author Rama, Luís ♦ Teixeira, Ana Maria ♦ Matos, Alice ♦ Borges, Grasiely ♦ Henriques, Ana ♦ Gleeson, Michael ♦ Pedreiro, Susana ♦ Filaire, Edith ♦ Alves, Francisco ♦ Paiva, Artur
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Immunity ♦ CD56 ♦ Upper respiratory symptoms ♦ Cortisol ♦ Human Physiology ♦ Occupational Medicine/Industrial Medicine ♦ Sports Medicine
Abstract Immune changes and increased susceptibility to infection are often reported in elite athletes. Infectious episodes can often impair training and performance with consequences for health and sporting success. This study monitored the occurrence of episodes of upper respiratory symptoms (URS) and the variation in circulating NK cells, CD56bright and CD56dim NK cells subpopulations, over a winter swimming season. Nineteen national elite swimmers and 11 non-athlete controls participated in this study. URS episodes were monitored using daily log books. Blood samples were taken at rest at four time points during the season: before the start of the season (t1—middle September), after 7 weeks of an initial period of gradually increasing training load (t2—early November), after 6 weeks of an intense training cycle (t3—late February) and 48 h after the main competition (t4—early April) and from the controls at three similar time points (t1—early November; t2—late February; t3—early April). In the swimmers, the occurrence of URS clustered around the periods of elevated training load (67 %). No URS were reported at equivalent time points in the non-athletes. Athletes showed a decrease in the percentage (t2 = 21 %; t3 = 27 %; t4 = 17 %) and absolute counts of circulating NK cells (t2 = 35 %; t3 = 22 %; t4 = 22 %), coinciding with the periods of increased training load, never recovering to the initial values observed at the start of the season. The reduction in the CD56dim and an increase in the CD56bright NK cell subpopulations were significant at t2 and t3 (p < 0.05). Concomitant with the fall in values of NK cells, in athletes that shown more than three URS episodes, a moderate correlation (r = 0.493; p = 0.036) was found between CD56bright/CD56dim ratio and the number of URS episodes after the more demanding training phase (t3). At t3, a lower value of CD56 cell counts was found in the group who reported three or more URS episodes (t = 2.239; p = 0.032). A progressive significant decrease in the expression of CD119, the receptor for IFN-γ, on the CD56dim cells was found over the season and an elevation in Granzyme B expression was coincident with the more demanding training phases. Periods of highly demanding training seem to have a negative impact on innate immunity mediated by NK cell subsets, which could partially explain the higher frequency of URS observed during these training phases.
ISSN 14396319
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-09-19
Publisher Place Berlin/Heidelberg
e-ISSN 14396327
Journal European Journal of Applied Physiology
Volume Number 113
Issue Number 4
Page Count 10
Starting Page 859
Ending Page 868

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Source: SpringerLink