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Author Ikeda, Teruaki
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2004
Language English
Abstract The inhibitory effects of various ion channel blockers were examined on in vitro excystment of Paragonimus ohirai metacercariae induced by a bile salt, sodium cholate. At a concentration of 10 µM, bepridil, a non-selective Ca2+ channel blocker, completely inhibited in vitro excystment, whereas TEA, lidocaine, and R(+)-IAA-94, channel blockers against K+, Na+ and Cl− ions, respectively, benzamil, an Na+/H+ and Na+/Ca2+ ion exchanger blocker, and R(+)-DIOA, a [K+, Cl−] cotransporter inhibitor, did not. Considering the previous result that Ca2+ ionophores are also efficient inducing factors for in vitro excystment of P. ohirai metacercariae and the present result, bile salts appear to induce the excystment of P. ohirai metacercariae through evoking the Ca2+ channels of target cells within the metacercarial juveniles.
ISSN 09320113
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2004-09-22
Publisher Place Berlin/Heidelberg
e-ISSN 14321955
Journal Parasitology Research
Volume Number 94
Issue Number 5
Page Count 3
Starting Page 329
Ending Page 331


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Source: SpringerLink