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Author Suzuki, Y. ♦ Takeda, M. ♦ Obara, N. ♦ Nagai, Y.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2001
Language English
Subject Domain (in DDC) Social sciences ♦ Sociology & anthropology
Abstract Our previous study has shown that ddY mice have special patches of nasal epithelium in the posterior roof of the nasal cavity that exclusively consists of olfactory supporting cells and horizontal basal cells. Here, we extend this finding to Balb/c and DBA/2 mice, Wistar and Sprague-Dawley rats, hamsters, and guinea pigs. In the mice, rats, and hamsters studied, the patches lacked olfactory cells and their precursor, globose basal cells. In rats and hamsters, the supporting cells were arranged in a single layer, in mice as three or four layers. Horizontal basal cells were located in a single layer in these species. In the guinea pigs, the specialized roof structure was less clear and could be seen at the level of ultrastructure as an olfactory neuron-lacking area. Distinct populations of transforming growth factor (TGF)-α-like immunoreactive olfactory cells occupied an area close to the epithelial patches. In this region, the TGF-α-like immunoreactive neurons were negative for the usual olfactory markers, either OMP or protein gene product (PGP) 9.5 or β-tubulin. These cells are suggested to project to the so-called ’necklace glomeruli’ and use a different cGMP-driven, transduction pathway. Three-dimensional analysis of double- labeled (TGF-α, PGP9.5) serial sections revealed a unique relation among the epithelial patches, TGF-α-like immunoreactive neurons and olfactory epithelium.
ISSN 03402061
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2001-04-27
Publisher Place Berlin/Heidelberg
e-ISSN 14320568
Journal Anatomy and Embryology
Volume Number 203
Issue Number 4
Page Count 9
Starting Page 239
Ending Page 247


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Source: SpringerLink