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Author Limberg, Jacqueline K. ♦ Evans, Trent D. ♦ Blain, Gregory M. ♦ Pegelow, David F. ♦ Danielson, Jessica R. ♦ Eldridge, Marlowe W. ♦ Proctor, Lester T. ♦ Sebranek, Joshua J. ♦ Schrage, William G.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Blood flow ♦ Functional hyperemia ♦ Prediabetes ♦ Exercise ♦ Occupational Medicine/Industrial Medicine ♦ Human Physiology ♦ Sports Medicine
Abstract This study was designed to test whether obese adults and adults with metabolic syndrome (MetSyn) exhibit altered hyperemic responses to hypoxia at rest and during forearm exercise when compared with lean controls. We hypothesized blood flow responses due to hypoxia would be lower in young obese subjects (n = 11, 24 ± 2 years, BMI 36 ± 2 kg m−2) and subjects with MetSyn (n = 8, 29 ± 3 years BMI 39 ± 2 kg m−2) when compared with lean adults (n = 13, 29 ± 2 years, BMI 24 ± 1 kg m−2). We measured forearm blood flow (FBF, Doppler Ultrasound) and arterial oxygen saturation (pulse oximetry) during rest and steady-state dynamic forearm exercise (20 contractions/min at 8 and 12 kg) under two conditions: normoxia (0.21 FiO2, ~98% SaO2) and hypoxia (~0.10 FiO2, 80% SaO2). Forearm vascular conductance (FVC) was calculated as FBF/mean arterial blood pressure. At rest, the percent change in FVC with hypoxia was greater in adults with MetSyn when compared with lean controls (p = 0.02); obese and lean adult responses were not statistically different. Exercise increased FVC from resting levels in all groups (p < 0.05). Hypoxia caused an additional increase in FVC (p < 0.05) that was not different between groups; responses to hypoxia were heterogeneous within and between groups. Reporting FVC responses as absolute or percent changes led to similar conclusions. These results suggest adults with MetSyn exhibit enhanced hypoxic vasodilation at rest. However, hypoxic responses during exercise in obese adults and adults with MetSyn were not statistically different when compared with lean adults. Individual hypoxic vasodilatory responses were variable, suggesting diversity in vascular control.
ISSN 14396319
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-06-09
Publisher Place Berlin/Heidelberg
e-ISSN 14396327
Journal European Journal of Applied Physiology
Volume Number 112
Issue Number 2
Page Count 11
Starting Page 699
Ending Page 709


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Source: SpringerLink