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Author Sun, Zihan ♦ Pei, Jing ♦ Cui, Fengyun ♦ Jing, Yanhua ♦ Hu, Chengjin
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword NHL ♦ IL-4 ♦ Association ♦ Polymorphism ♦ Meta-analysis ♦ Cancer Research
Abstract The relationship of non-Hodgkin’s lymphoma (NHL) with the presence of interleukin-4 genetic polymorphism -588C>T has been reported with inconsistent results. The objective of this study was to quantitatively evaluate the association between -588C>T polymorphism and NHL susceptibility. Two investigators independently searched Medline and the Cochrane Library up to September 20, 2013. Pooled odds ratio and 95 % confidence interval were calculated using a fixed or random effects model. Statistical analysis was performed with Review Manage 5.0 and Stata 11. Of the six case-control studies selected for this meta-analysis, a total of 1,909 NHL cases and 1,834 controls were included. The combined results based on all studies suggested that -588C>T was not associated with NHL risk under all genetic models. When stratifying for race, no noteworthy associations were observed in mixed populations or Caucasians. This meta-analysis suggests that IL-4 -588C>T polymorphism might not be a risk factor for NHL risk. However, further well-designed studies are required to confirm our findings.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-01-26
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 35
Issue Number 5
Page Count 4
Starting Page 4897
Ending Page 4900

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Source: SpringerLink