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Author Fan, Dong Mei ♦ Tian, Xiao Yu ♦ Wang, Rui Fang ♦ Yu, Juan Juan
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword ERα ♦ TGF-β1 ♦ Cervical adenocarcinoma ♦ Human papillomavirus ♦ Prognosis ♦ Cancer Research
Abstract The incidence of stage Ib ~ IIa of cervical adenocarcinoma accounts about 60 to 70 % of all patients. This study aims to investigate the prognostic significance of protein estrogen receptor alpha (ERα) and transforming growth factor beta 1 (TGF-β1) level in different glandular epithelia of the cervix. In this study, immunohistochemistry was used to detect ERα and TGF-β1 in carcinomas and incisal margins of 66 cases with cervical adenocarcinoma, 20 cases with normal cervix, and 20 cases with chronic cervicitis. Uni- and multivariate analysis was applied to evaluate the prognostic significance of TGF-β1 and ERα in carcinomas. The results indicated that the positive expression of TGF-β1 in carcinomas was 71.21 %, significantly higher compared to that in the normal cervix (35 %) and chronic cervicitis (55 %) (χ $^{2}$ = 8.901, P = 0.012). Similarly, the positive expression of ERα in the carcinomas was 68.18 %, significantly higher compared to the normal cervix (35 %) and chronic cervicitis (50 %) (χ $^{2}$ = 7.693, P = 0.021). Both TGF-β1 and ERα in the carcinomas were associated with the vaginal recurrence, infection of HPV, depth of infiltration, and lymphatic metastasis (P < 0.05). The conjugation of TGF-β1 and ERα was an independent prognostic factor for cervical adenocarcinoma. Survival curve showed that the positive TGF-β1 and ERα indicated a short lifetime of patient with cervical adenocarcinoma. In conclusion, the expression of TGF-β1 and ERα protein in the carcinomas had a significant prognostic value in a patient of stage Ib ~ IIa in cervical adenocarcinoma.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-08-12
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 35
Issue Number 11
Page Count 6
Starting Page 11237
Ending Page 11242


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Source: SpringerLink