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Author Araújo, Rubistenia Miranda Soares ♦ Melo, Cynthia Farias Vieira ♦ Neto, Fidelis Manes ♦ Silva, Juarez Nóbrega ♦ Soares, Leonardo Ferreira ♦ Arruda Cardoso Smith, Marilia ♦ Sousa, Edilson Carvalho ♦ Burbano, Rommel Mario Rodríguez ♦ Medeiros, Arnaldo Correia ♦ Lima, Eleonidas Moura
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword SNPs ♦ Gastric cancer ♦ GSTP1 ♦ Cancer Research
Abstract Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ $^{2}$ = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-01-23
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 35
Issue Number 5
Page Count 4
Starting Page 4983
Ending Page 4986

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Source: SpringerLink