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Author Takahashi, Kengo ♦ Kaira, Kyoichi ♦ Shimizu, Akira ♦ Sato, Taisuke ♦ Takahashi, Norifumi ♦ Ogawa, Hiroomi ♦ Yoshinari, Daisuke ♦ Yokobori, Takehiko ♦ Asao, Takayuki ♦ Takeyoshi, Izumi ♦ Oyama, Tetsunari
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2016
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword β2-adrenergic receptor ♦ Gastric cancer ♦ Prognosis ♦ Immunohistochemistry ♦ β2-blocker ♦ Cancer Research
Abstract The β2-adrenergic receptor (β2-AR) is highly expressed in various human neoplasms and has been considered a novel therapeutic target of cancer treatment. However, the clinicopathological significance of β2-AR expression in patients with gastric cancer (GC) remains unclear. The aim of this study was to explore β2-AR expression and its prognostic significance. A total of 331 patients with surgically resected GC were evaluated. Tumor sections were stained immunohistochemically for β2-AR. And, we confirmed β2-AR expression in the GC cell lines by Western blot. β2-AR was highly expressed in 30.5 % of GC patients. Expression was significantly associated with age, T factor, tumor differentiation, histology of non-signet cells, lymphatic permeation, and vascular invasion. And, all the GC cell lines expressed β2-AR. On univariate analysis, age, disease stage, T factor, N factor, lymphatic permeation, vascular invasion, and β2-AR expression were significantly associated with overall survival. Although the multivariate analysis did not indicate that β2-AR expression was independently prognostic of survival, high-level β2-AR expression was associated with significantly poorer survival of GC patients with well or moderately differentiated tumors. β2-AR expression was a significant predictor of tumor aggressiveness in, and poorer survival of, patients with GC.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-08-03
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 37
Issue Number 10
Page Count 8
Starting Page 13885
Ending Page 13892


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Source: SpringerLink