### Association between XRCC3 Thr241Met polymorphism and colorectal cancer riskAssociation between XRCC3 Thr241Met polymorphism and colorectal cancer risk

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 Author Wang, ZhiZhen ♦ Zhang, Wencheng Source SpringerLink Content type Text Publisher Springer Netherlands File Format PDF Copyright Year ©2012 Language English
 Subject Domain (in DDC) Technology ♦ Medicine & health Subject Keyword Colorectal cancer ♦ X-ray repair cross-complementing group 3 ♦ Genetic polymorphism ♦ Meta-analysis ♦ Cancer Research Abstract The x-ray repair cross-complementing group 3 (XRCC3), a member of DNA repair genes, plays a critical role in the maintenance of genome stability by homologous recombination repair for DNA double-strand breaks. The polymorphism of XRCC3 Thr241Met has been indicated to be involved in the development of some cancers, but previous individual studies on the association between XRCC3 Thr241Met polymorphism and colorectal cancer (CRC) risk have yielded conflicting and inconclusive results. To shed some light on the contradictory findings and improve our understanding of the pathogenesis of CRC, we carried out this updated meta-analysis by pooling all available publications. Databases including PubMed, Embase, Web of Science and China National Knowledge Infrastructure were searched for relevant publications. The odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to estimate the strength of the association between XRCC3 Thr241Met polymorphism and CRC risk. A total of 15 case–control studies involving 4,475 cases and 6,373 controls were included. Overall, the pooled ORs for the meta-analysis of total included studies showed no statistically significant association of XRCC3 Thr241Met polymorphism with CRC risk in any genetic model (OR$_{Met allele vs. Thr allele}$ = 1.17, 95 % CI 0.97–1.42, P $_{OR}$ = 0.102; OR$_{MetMet vs. ThrThr}$ = 1.32, 95 % CI 0.93–1.87, P $_{OR}$ = 0.121; OR$_{ThrMet vs. ThrThr}$ = 1.17, 95 % CI 0.94–1.45, P $_{OR}$ = 0.150; OR$_{MetMet + ThrMet vs. ThrThr}$ = 1.20, 95 % CI 0.96–1.51, P $_{OR}$ = 0.114; OR$_{MetMet vs. ThrThr + ThrMet}$ = 1.37, 95 % CI 0.98–1.93, P $_{OR}$ = 0.065). However, in subgroup analyses stratified by source of controls and ethnicity, the XRCC3 Thr241Met polymorphism was associated with an elevated risk of CRC in the hospital-based case–control studies and the Asian population. Sensitivity analysis indicated that the findings were unlikely due to chance. This meta-analysis suggests that the XRCC3 Thr241Met polymorphism may modify the risk of CRC, particularly in Asians. ISSN 10104283 Age Range 18 to 22 years ♦ above 22 year Educational Use Research Education Level UG and PG Learning Resource Type Article Publisher Date 2013-03-17 Publisher Place Dordrecht e-ISSN 14230380 Journal Tumor Biology Volume Number 34 Issue Number 3 Page Count 9 Starting Page 1421 Ending Page 1429