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Author Kim, Min Sang ♦ Lee, Doo Sung ♦ Choi, Eun Kyung ♦ Park, Heon Joo ♦ Kim, Jin Seok
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2005
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences
Subject Keyword pH-sensitive polymer ♦ pK$_{ b }$ ♦ molecular weight control ♦ Polymer Sciences ♦ Soft and Granular Matter, Complex Fluids and Microfluidics ♦ Physical Chemistry ♦ Characterization and Evaluation of Materials ♦ Nanochemistry ♦ Nanotechnology
Abstract The main objective of this study was to modulate pH-sensitive polymers(poly(β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by$^{1}$HNMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.
ISSN 15985032
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2005-01-01
Publisher Place Berlin, Heidelberg
e-ISSN 20927673
Journal Macromolecular Research
Volume Number 13
Issue Number 2
Page Count 5
Starting Page 147
Ending Page 151


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Source: SpringerLink