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Author Aravind, Athulya ♦ Yoshida, Yasuhiko ♦ Maekawa, Toru ♦ Kumar, D. Sakthi
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Nanoparticles ♦ Polymers ♦ Targeted Drug delivery ♦ Aptamers ♦ Antibodies ♦ Cancer therapy ♦ Pharmaceutical Sciences/Technology
Abstract Recent advances in cancer nanotechnology have led to the emergence of aptamer-enabled technologies to diagnose and treat cancer. Aptamers with their high binding sensitivity and specificity are highly attractive for a wide variety of applications in molecular targeting. Aptamer-escorted drug-loaded polymeric nanoparticles represent a promising technology, which facilitates controlled release and targeted approach to deliver drugs to the desired site with marginal or any collateral damage. By properly integrating these nanobased approaches with the established cancer research findings could help to resolve some of the existing problems in the current conventional cancer therapy. In this review, we discuss the progresses achieved in the aptamer mediated nanoparticle drug delivery and properties of nanoparticles, which play a significant role in developing the aptamer–nanoparticle bioconjugates. In addition, we highlight the recent preclinical works involving these bioconjugates as cancer therapeutics.
ISSN 2190393X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-09-13
Publisher Institution Controlled Release Society
Publisher Place Boston
e-ISSN 21903948
Journal Drug Delivery and Translational Research
Volume Number 2
Issue Number 6
Page Count 19
Starting Page 418
Ending Page 436


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Source: SpringerLink