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Author Rosenfeld, Jeffrey ♦ Strong, Michael J.
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2015
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Motor neuron disease ♦ Biomarkers ♦ Disease heterogeneity ♦ Genetic markers ♦ Clinical spectrum ♦ Neurosciences ♦ Neurology ♦ Neurosurgery ♦ Neurobiology
Abstract With the acceleration in our understanding of ALS and the related motor neuron disease has come even greater challenges in reconciling all of the proposed pathogenic mechanisms and how this will translate into impactful treatments. Fundamental issues such as diagnostic definition(s) of the disease spectrum, relevant biomarkers, the impact of multiple novel genetic mutations and the significant effect of symptomatic treatments on disease progression are all areas of active investigation. In this review, we will focus on these key issues and highlight the challenges that confront both clinicians and basic science researchers.
ISSN 19337213
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-01-09
Publisher Institution American Society for Experimental NeuroTherapeutics
Publisher Place New York
e-ISSN 18787479
Journal NeuroRX
Volume Number 12
Issue Number 2
Page Count 9
Starting Page 317
Ending Page 325

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Source: SpringerLink