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Author Zhong, Shan ♦ Yang, Jia He ♦ Liu, Kai ♦ Jiao, B. H. ♦ Chang, Zhi Jie
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword MTHFR C677T ♦ Genetic polymorphism ♦ Meta-analysis ♦ Colorectal cancer ♦ Cancer Research
Abstract A great number of studies regarding the association between MTHFR C677T polymorphism and risk of colorectal cancer (CRC) in East Asians were published, but the results were inconsistent. Thus, a meta-analysis was performed to investigate the association. PubMed, Embase, and CBM databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were calculated using random or fixed effect models. Finally, 24 case–control studies with a total of 7,230 CRC cases and 9,285 controls were included. Meta-analyses of a total of 24 studies showed there was a statistically significant association between MTHFR C677T polymorphism and decreased CRC risk in East Asians under four genetic models (T versus C, OR = 0.92, 95 % CI 0.85–0.99; TT versus CC, OR = 0.80, 95 % CI 0.69–0.94; TT versus CT/CC, OR = 0.82, 95 % CI 0.71–0.95; TT/CT versus CC, OR = 0.92, 95 % CI 0.86–0.98). The cumulative meta-analyses for the allele contrast (T versus C), homozygote (TT versus CC), dominant (TT/CT versus CC), and recessive (TT versus CT/CC) models all showed a trend of more obvious association as information accumulated by year. Subgroup analyses by country further identified this association in Korea and Japan. This meta-analysis suggests that MTHFR C677T polymorphism is associated with decreased risk of colorectal cancer in East Asians, and MTHFR 677T variant has a protective effect on colorectal cancer.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-08-15
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 33
Issue Number 6
Page Count 11
Starting Page 2041
Ending Page 2051


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Source: SpringerLink