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Author Minina, V. I. ♦ Druzhinin, V. G. ♦ Glushkov, A. N. ♦ Golovina, T. A. ♦ Apalko, S. V. ♦ Volkov, A. N. ♦ Ahmatjanova, V. R. ♦ Lunina, A. A. ♦ Larionov, A. V.
Source SpringerLink
Content type Text
Publisher SP MAIK Nauka/Interperiodica
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword chromosomal aberrations ♦ CYPlA genotype ♦ radon ♦ heavy metals ♦ Human Genetics
Abstract The correlation between the level of chromosomal aberrations and CYP1A genotypes in adolescents of the Tashtagol boarding school (Kemerovo region) exposed to a combined effect of high doses of radon and heavy metals has been studied. It was found that the level of chromosomal aberrations shows a statistically significantly increase in carriers of at least one CYP1A1*2A (A2455G) allele. The frequency of ring chromosomes shows a statistically significant increase in carriers of the CYP1A1 *1A*1A (T3801C) genotype. The frequency of multiple chromosomal aberrations was higher in carriers of the CYP1A2*1A*1A genotype. A conclusion on the important role of polymorphic CYP1A loci in genotoxic effects of radon and heavy metals is made.
ISSN 20790597
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-05-01
Publisher Place Dordrecht
e-ISSN 20790600
Journal Russian Journal of Genetics: Applied Research
Volume Number 1
Issue Number 2
Page Count 7
Starting Page 121
Ending Page 127


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Source: SpringerLink