|Author||Minina, V. I. ♦ Druzhinin, V. G. ♦ Glushkov, A. N. ♦ Golovina, T. A. ♦ Apalko, S. V. ♦ Volkov, A. N. ♦ Ahmatjanova, V. R. ♦ Lunina, A. A. ♦ Larionov, A. V.|
|Publisher||SP MAIK Nauka/Interperiodica|
|Subject Domain (in DDC)||Technology ♦ Medicine & health|
|Subject Keyword||chromosomal aberrations ♦ CYPlA genotype ♦ radon ♦ heavy metals ♦ Human Genetics|
|Abstract||The correlation between the level of chromosomal aberrations and CYP1A genotypes in adolescents of the Tashtagol boarding school (Kemerovo region) exposed to a combined effect of high doses of radon and heavy metals has been studied. It was found that the level of chromosomal aberrations shows a statistically significantly increase in carriers of at least one CYP1A1*2A (A2455G) allele. The frequency of ring chromosomes shows a statistically significant increase in carriers of the CYP1A1 *1A*1A (T3801C) genotype. The frequency of multiple chromosomal aberrations was higher in carriers of the CYP1A2*1A*1A genotype. A conclusion on the important role of polymorphic CYP1A loci in genotoxic effects of radon and heavy metals is made.|
|Age Range||18 to 22 years ♦ above 22 year|
|Education Level||UG and PG|
|Learning Resource Type||Article|
|Journal||Russian Journal of Genetics: Applied Research|
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