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Author Wu, Wen Jie ♦ Shi, Jia ♦ Hu, Gang ♦ Yu, Xin ♦ Lu, Han ♦ Yang, Ming Liang ♦ Liu, Bin ♦ Wu, Zhi Xiang
Source SpringerLink
Content type Text
Publisher Springer Netherlands
File Format PDF
Copyright Year ©2015
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Hepatocellular carcinoma (HCC) ♦ FBXW7 ♦ MicroRNA-770 ♦ Wnt/β catenin ♦ Cancer Research
Abstract FBXW7 (F-box and WD repeat domain-containing 7) is the F-box protein component of a Skp1–Cul1–F-box protein–type (SCF-type) ubiquitin ligase. Previous studies have shown that FBXW7 serves as a tumor suppressor and is frequently downregulated in many types of human neoplasms. However, the molecular mechanisms for its downregulation remain poorly understood. Hyperactivation of Wnt/β-catenin signaling pathway is viewed as crucial for tumorigenesis, including hepatocellular carcinoma (HCC). In the present study, we show that protein levels, but not message RNA, of FBXW7 were suppressed by Wnt3a treatment or transfection of a constitutively activated β-catenin in HCC cells. Besides, microRNA-770 was identified as an important downstream target of Wnt/β-catenin signaling, to inhibit FBXW7 expression through targeting its 3′-untranslated region. Thus, our results suggest a previously unknown Wnt/β catenin–miR-770–FBXW7 molecular network in the HCC development.
ISSN 10104283
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-11-24
Publisher Place Dordrecht
e-ISSN 14230380
Journal Tumor Biology
Volume Number 37
Issue Number 5
Page Count 7
Starting Page 6045
Ending Page 6051

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Source: SpringerLink