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Author Ali, Ahmed A.A. ♦ Settin, Ahmad A.
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Springer
File Format HTM / HTML
Date Created 2017-01-16
Copyright Year ©2013
Language English
Subject Domain (in LCC) QL1-991
Subject Keyword IL-10 ♦ IL-1Ra ♦ TNF-α ♦ Science ♦ Gene polymorphism ♦ Cytokines ♦ Asthma ♦ IL-6 ♦ Zoology
Abstract Background: Asthma is a multifactorial inflammatory disorder that might result from the interaction of multiple genes and environmental factors. Several studies of genetic epidemiology have reported the association of cytokine genes with asthma among various populations. However, the results are inconsistent and inconclusive. Objective: To determine the association of cytokine gene polymorphisms with asthma susceptibility in adult Egyptian cases. Subjects: The study included, 50 adult Egyptian asthmatic cases with a mean age of 53.62 ± 14.61 years in addition to 98 healthy individuals as control. For all participants, DNA was isolated from peripheral blood samples and analyzed for TNF-α-308 G > A, IL-10-1082 G > A, IL-6-174 G > C and IL-1Ra VNTR polymorphisms. Results: The comparison between the cases and controls has showed significantly higher frequency of the genotypic polymorphisms: IL-10-1082 AG + GG (dominant mode) (76.1% vs. 91.8%, p = 0.01, OR = 0.3, 95% CI (0.1–0.7), TNF-α-308 GA + AA (dominant mode) (72.0% vs. 93.9%, p = 0.001, OR = 0.17, 95% CI = 0.06–0.47) and IL-1RA VNTR heterozygous genotype A1A2 (90.0% vs. 58.8%, p = 0.0003). Otherwise, compared to controls, cases showed statistically non-significant frequency of genotypes corresponding to IL-6-174 CC + GC vs. GG (dominant mode) (92.0% vs. 94.9%, p = 0.5, OR = 0.6). Conclusions: The IL-10, TNF-α and IL-1Ra allelic variants showed a potent association with chronic asthma among Egyptian cases that might be used as markers with a potential impact on prophylactic and or therapeutic measures for asthma control. Whereas the IL-6-174 allelic variants showed no association with chronic asthma among Egyptian cases.
ISSN 20909896
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2013-08-01
e-ISSN 20909896
Journal Journal of Basic and Applied Zoology
Volume Number 66
Issue Number 4
Page Count 7
Starting Page 188
Ending Page 194


Source: Directory of Open Access Journals (DOAJ)