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Author Huang, Yu-Jie ♦ Liao, Hsin-Hung ♦ Huang, Pen-Li ♦ Wang, Tao ♦ Yang, Yao-Joe ♦ Wang, Yao-Hong ♦ Lu, Shey-Shi
Source ACM Digital Library
Content type Text
Publisher Association for Computing Machinery (ACM)
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Biocompatibility ♦ CMOS SoC ♦ Drug delivery ♦ Electrothermal ♦ Implantable ♦ Post-IC
Abstract An implantable system-on-a-chip (SoC) integrating controller/actuation circuitry and 8 individually addressable drug reservoirs is proposed for on-demand drug delivery. It is implemented by standard $0.35-\textit{μ}m$ CMOS technology and post-IC processing. The post-IC processing includes deposition of metallic membranes (200Å Pt/3000Å Ti/200Å Pt) to cap the drug reservoirs, deep dry etching to carve drug reservoirs in silicon as drug containers, and PDMS layer bonding to enlarge the drug storage. Based on electrothermal activation technique, drug releases can be precisely controlled by wireless signals. The wireless controller/actuation circuits including on-off keying (OOK) receiver, microcontroller unit, clock generator, power-on-reset circuit, and switch array are integrated on the same chip, providing patients the ability of remote drug activation and noninvasive therapy modification. Implanted by minimally invasive surgery, this SoC can be used for the precise drug dosing of localized treatment, such as the cancer therapy, or the immediate medication to some emergent diseases, such as heart attack. In vitro experimental results show that the reservoir content can be released successfully through the rupture of the membrane which is appointed by received wireless commands.
ISSN 15504832
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-06-01
Publisher Place New York
e-ISSN 15504840
Journal ACM Journal on Emerging Technologies in Computing Systems (JETC)
Volume Number 8
Issue Number 2
Page Count 22
Starting Page 1
Ending Page 22


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Source: ACM Digital Library