Access Restriction

Author Weng, Xiuhong ♦ Liu, Yi ♦ Cheng, Bo ♦ Cui, Shun
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher BioMed Central
File Format HTM / HTML
Date Created 2018-09-09
Copyright Year ©2018
Language English
Subject Domain (in LCC) RC925-935
Subject Keyword Primary Sjögren’s syndrome ♦ Inverse agonist ♦ Internal medicine ♦ Focus score ♦ RORα ♦ Th17 cells ♦ Medicine ♦ Diseases of the musculoskeletal system ♦ Specialties of internal medicine
Abstract Abstract Background The orphan nuclear receptors retinoic acid-related receptor α and γt (RORα and RORγt) are critical in the development of T helper 17 (Th17) cells, and ROR-specific synthetic ligands have proven efficacy in several mouse models of autoimmunity. However, the pathological significance of RORα in primary Sjögren’s syndrome (pSS) remains to be elucidated. The present study was designed to clarify the significance of RORα in the pathogenesis of pSS. Methods RORα expression in the labial salivary gland (LSG) was determined by immunohistochemical analysis using a quantitative scoring system in 34 patients with pSS. The correlation between RORα expression in LSGs and the focus score (FS) was determined, and Th17 and IL-17 receptor A (1L-17RA) levels in LSGs were determined. To investigate the effect of RORs and the therapeutic potential of targeting RORs in pSS, we administered SR1001, a selective RORα/γt inverse agonist, to non-obese diabetic (NOD) mice. Results The expression of RORα was significantly increased in LSGs of patients with pSS and intensified with disease stage/FS, showing a similar increasing trend with IL-17A and IL-17RA. SR1001 significantly improved salivary gland secretory function and relieved sialadenitis in treated mice. Conclusion Our data reveal the importance of RORα in controlling pathologic lymphocytic infiltration of the salivary glands and suggest that RORα may be a druggable target in treating pSS.
ISSN 14786362
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2018-09-01
e-ISSN 14786354
Journal Arthritis Research & Therapy
Volume Number 20
Issue Number 1
Page Count 12
Starting Page 1
Ending Page 12

Source: Directory of Open Access Journals (DOAJ)