Thumbnail
Access Restriction
Open

Author MacDermaid, Christopher M. ♦ Klein, Michael L. ♦ Fiorin, Giacomo ♦ Kashyap, Hemant K. ♦ DeVane, Russell H. ♦ Shinoda, Wataru ♦ Klauda, Jeffery B.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ♦ ALKANES ♦ BENDING ♦ CHOLESTEROL ♦ COMPARATIVE EVALUATIONS ♦ COMPUTERIZED SIMULATION ♦ LAYERS ♦ LIQUIDS ♦ MEMBRANES ♦ MIXTURES ♦ MOLECULAR DYNAMICS METHOD ♦ MOLECULES ♦ ORDER PARAMETERS ♦ PHOSPHOLIPIDS ♦ PROTEINS
Abstract The architecture of a biological membrane hinges upon the fundamental fact that its properties are determined by more than the sum of its individual components. Studies on model membranes have shown the need to characterize in molecular detail how properties such as thickness, fluidity, and macroscopic bending rigidity are regulated by the interactions between individual molecules in a non-trivial fashion. Simulation-based approaches are invaluable to this purpose but are typically limited to short sampling times and model systems that are often smaller than the required properties. To alleviate both limitations, the use of coarse-grained (CG) models is nowadays an established computational strategy. We here present a new CG force field for cholesterol, which was developed by using measured properties of small molecules, and can be used in combination with our previously developed force field for phospholipids. The new model performs with precision comparable to atomistic force fields in predicting the properties of cholesterol-rich phospholipid bilayers, including area per lipid, bilayer thickness, tail order parameter, increase in bending rigidity, and propensity to form liquid-ordered domains in ternary mixtures. We suggest the use of this model to quantify the impact of cholesterol on macroscopic properties and on microscopic phenomena involving localization and trafficking of lipids and proteins on cellular membranes.
ISSN 00219606
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-12-28
Publisher Place United States
Journal Journal of Chemical Physics
Volume Number 143
Issue Number 24


Open content in new tab

   Open content in new tab