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Author Huang, Jung Y. ♦ Lin, Chien Y.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ♦ DIFFUSION ♦ DIMERIZATION ♦ DIMERS ♦ FLUCTUATIONS ♦ GROWTH FACTORS ♦ IN VIVO ♦ LIGANDS ♦ MEMBRANES ♦ MOLECULES ♦ POTENTIALS ♦ RECEPTORS ♦ STOCHASTIC PROCESSES ♦ VISIBLE RADIATION
Abstract Ligand-induced receptor dimerization plays a crucial role in the signaling process of living cells. In this study, we developed a theoretical model and performed single-molecule tracking to explore the correlated diffusion processes of liganded epidermal growth factor receptors prior to dimer formation. We disclosed that both an attractive potential between liganded receptor proteins in proximity and correlated fluctuations in the local environments of the proteins play an important role to produce the observed correlated movement of the receptors. This result can serve as the foundation to shed light on the way in which receptor functions are regulated in plasma membranes in vivo.
ISSN 00219606
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-12-14
Publisher Place United States
Journal Journal of Chemical Physics
Volume Number 143
Issue Number 22


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