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Author Koo, S. I. ♦ Algilani, K. ♦ Norvell, J. E. ♦ Henderson, D. A.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BASIC BIOLOGICAL SCIENCES ♦ CHOLESTEROL ♦ BLOOD-PLASMA CLEARANCE ♦ ZINC ♦ BIOLOGICAL EFFECTS ♦ NUTRITIONAL DEFICIENCY ♦ CARBON 14 COMPOUNDS ♦ CHYLOMICRONS ♦ LIVER ♦ RATS ♦ ANIMALS ♦ BODY ♦ CLEARANCE ♦ DIGESTIVE SYSTEM ♦ ELEMENTS ♦ GLANDS ♦ HYDROXY COMPOUNDS ♦ LABELLED COMPOUNDS ♦ MAMMALS ♦ METALS ♦ ORGANIC COMPOUNDS ♦ ORGANS ♦ RODENTS ♦ STEROIDS ♦ STEROLS ♦ VERTEBRATES ♦ Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ♦ Physiological Systems- Tracer Techniques
Abstract Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.
Educational Use Research
Learning Resource Type Article
Publisher Date 1986-03-01
Publisher Place United States
Journal Am. J. Clin. Nutr.
Volume Number 3
Organization Oral Roberts Univ. School of Medicine, Tulsa, OK


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