|Author||Koo, S. I. ♦ Algilani, K. ♦ Norvell, J. E. ♦ Henderson, D. A.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BASIC BIOLOGICAL SCIENCES ♦ CHOLESTEROL ♦ BLOOD-PLASMA CLEARANCE ♦ ZINC ♦ BIOLOGICAL EFFECTS ♦ NUTRITIONAL DEFICIENCY ♦ CARBON 14 COMPOUNDS ♦ CHYLOMICRONS ♦ LIVER ♦ RATS ♦ ANIMALS ♦ BODY ♦ CLEARANCE ♦ DIGESTIVE SYSTEM ♦ ELEMENTS ♦ GLANDS ♦ HYDROXY COMPOUNDS ♦ LABELLED COMPOUNDS ♦ MAMMALS ♦ METALS ♦ ORGANIC COMPOUNDS ♦ ORGANS ♦ RODENTS ♦ STEROIDS ♦ STEROLS ♦ VERTEBRATES ♦ Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ♦ Physiological Systems- Tracer Techniques|
|Abstract||Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Journal||Am. J. Clin. Nutr.|
|Organization||Oral Roberts Univ. School of Medicine, Tulsa, OK|
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