|Author||Vos, O. ♦ Van Der Schans, G. P. ♦ Roos-Verhey, W. S. D.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BASIC BIOLOGICAL SCIENCES ♦ CELL KILLING ♦ RADIOINDUCTION ♦ HELA CELLS ♦ BIOLOGICAL RADIATION EFFECTS ♦ IMINES ♦ RADIOSENSITIVITY EFFECTS ♦ MALEIC ACID ♦ STRAND BREAKS ♦ BIOLOGICAL REPAIR ♦ THIOLS ♦ BIOCHEMISTRY ♦ COBALT 60 ♦ DNA ♦ GAMMA RADIATION ♦ GLUTATHIONE ♦ SURVIVAL CURVES ♦ X RADIATION ♦ BETA DECAY RADIOISOTOPES ♦ BETA-MINUS DECAY RADIOISOTOPES ♦ BIOLOGICAL EFFECTS ♦ BIOLOGICAL RECOVERY ♦ CARBOXYLIC ACIDS ♦ CHEMISTRY ♦ COBALT ISOTOPES ♦ DICARBOXYLIC ACIDS ♦ DRUGS ♦ ELECTROMAGNETIC RADIATION ♦ INTERMEDIATE MASS NUCLEI ♦ INTERNAL CONVERSION RADIOISOTOPES ♦ IONIZING RADIATIONS ♦ ISOMERIC TRANSITION ISOTOPES ♦ ISOTOPES ♦ MINUTES LIVING RADIOISOTOPES ♦ NUCLEI ♦ NUCLEIC ACIDS ♦ ODD-ODD NUCLEI ♦ ORGANIC ACIDS ♦ ORGANIC COMPOUNDS ♦ ORGANIC NITROGEN COMPOUNDS ♦ ORGANIC SULFUR COMPOUNDS ♦ PEPTIDES ♦ POLYPEPTIDES ♦ PROTEINS ♦ RADIATION EFFECTS ♦ RADIATIONS ♦ RADIOISOTOPES ♦ RADIOPROTECTIVE SUBSTANCES ♦ RECOVERY ♦ REPAIR ♦ YEARS LIVING RADIOISOTOPES ♦ Radiation Effects on Cells- External Source- (-1987) ♦ Biochemistry|
|Abstract||Reduction of the intracellular GSH and NPSH levels in HeLa cells by BSO and DEM treatments was determined. As parameters for radiation damage, single and double strand DNA breaks (ssb and dsb) and cell killing were used. Furthermore, repair of ssb and dsb were followed in the first 30 and 120 min after radiation, respectively. BSO and DEM treatment gave a small sensitization for the 3 types of radiation damage (ssb, dsb and cell killing) in aerobic condition. In hypoxic condition the sensitizing effect of both compounds on dsb was larger than the effect on ssb. Pretreatment with BSO and DEM had no influence on repair of ssb and dsb when cells were irradiated in air, but when cells were irradiated in hypoxia, repair was somewhat inhibited after pretreatment with DEM. It can be postulated that a reduction of the intracellular GSH level by BSO and DEM treatment affects cellular radiosensitivity both by a competitive mechanism between GSH and O/sub 2/ and by inhibition of enzymatic repair of DNA breaks, the latter only in the case of DEM treatment.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Journal||Int. J. Radiat. Oncol., Biol. Phys.|
|Organization||Medical Biological Lab. TNO, Rijswijk, Netherlands|
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