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Author Hoult, J. R. ♦ Robinson, C.
Source PubMed Central
Content type Text
Publisher Nature Publishing Group
File Format PDF
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health
Abstract 1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F2 alpha under similar conditions. 3 The pulmonary disposition of thromboxane B2, which occurs by uptake into pulmonary cells or binding to a specific macromolecular component, is mediated by a mechanism distinct from that handling prostaglandin F2 alpha. The possible relevance of these findings to the pulmonary disposition of thromboxane A2 is discussed.
ISSN 00071188
Age Range above 22 year
Educational Use Research
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 1983-01-01
Rights Holder Nature Publishing Group
Journal British Journal of Pharmacology
Volume Number 78
Issue Number 1
Starting Page 85


Source: PubMed Central